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Roy Simons

Drs. Roy Simons

About

Hi, I am Roy, I have a background in biotechnology as I studied Life Science & Technology at Delft University of Technology. During my masters I was drawn into both the synthetic biology and bioinformatics fields of the Life Sciences. I gained more experience in bioinformatics after completing my internship at Microba, an Australian-based gut microbiome company. Finally I finished my masters in 2020 by collaborating on the development of a high throughput method for single-molecule FRET experiments, combining single molecule fluorescence microscopy with next generation sequencing.

On April 2021 I started my PhD at the Vidaki lab here at the Erasmus Medical Center. The goal of this PhD, with the support of Erasmus MC, is to develop CpGtracer: a targeted DNA methylation analysis method for the analysis of low-quality and -quantity input DNA. One of the applications on which CpGtracer will first be tested is in collaboration with the Adams lab for the analysis of cell-free DNA obtained from liquid biopsies in order to detect biomarkers related to neurological diseases, resulting in less invasive and more accurate diagnostics.

Positions

  • PhD researcher, department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands

Publications

News

Oh what a year!
Oh what a year!
New grant awarded!
New grant awarded!
Review on genetic influences on hippocampal subfields published in Neurology Genetics
Review on genetic influences on hippocampal subfields published in Neurology Genetics
Hieab Adams wins Erasmus MC Fellowship!
Hieab Adams wins Erasmus MC Fellowship!
Cortical regions of interest GWAS published in Nature Communications
Cortical regions of interest GWAS published in Nature Communications
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Projects

Strategies for integrated analysis in Neurogenetic / Imaging Genetics studies

Strategies for integrated analysis in Neurogenetic / Imaging Genetics studies

Uncovering the genetic characterization of hippocampal subfields

Uncovering the genetic characterization of hippocampal subfields

Evaluating brain atrophy as an endophenotype for genetic studies of neurodegeneration

Evaluating brain atrophy as an endophenotype for genetic studies of neurodegeneration

Inheritance patterns of polygenic risk scores

Inheritance patterns of polygenic risk scores

Migraine genetic variants and their influence on cerebral blood flow

Migraine genetic variants and their influence on cerebral blood flow

Genetic correction of hippocampal volume in dementia prediction

Genetic correction of hippocampal volume in dementia prediction

Gene expression and its effects on the cerebral cortex

Gene expression and its effects on the cerebral cortex

Genetic factors predisposing to brain microbleeds

Genetic factors predisposing to brain microbleeds

Population-based induction of pluripotent stem cells

Population-based induction of pluripotent stem cells

Genome-wide association study of human head size

Genome-wide association study of human head size

Genetics of cognition and markers of neurodevelopment and neurodegeneration

Genetics of cognition and markers of neurodevelopment and neurodegeneration

Orbital telorism and neural correlates

Orbital telorism and neural correlates

Heritability and genome-wide association studies of orbital telorism

Heritability and genome-wide association studies of orbital telorism

Does polygenic burden for late-life neurodegeneration relate to early-life processes?

Does polygenic burden for late-life neurodegeneration relate to early-life processes?

Genetic scores for region-specific subcortical volume during adulthood generalize to infancy and early childhood

Genetic scores for region-specific subcortical volume during adulthood generalize to infancy and early childhood

qdecR: an R package for surface-wide analyses of FreeSurfer segmentations

qdecR: an R package for surface-wide analyses of FreeSurfer segmentations

Determinants of enrichment of genetic variant association- a genome wide association perspective

Determinants of enrichment of genetic variant association- a genome wide association perspective

High-dimensional imaging markers and neurodegenerative disorders: a pilot study

High-dimensional imaging markers and neurodegenerative disorders: a pilot study

Genetics of brain-derived neurotrophic factor: the CHARGE consortium

Genetics of brain-derived neurotrophic factor: the CHARGE consortium

Genetic architecture of subcortical brain structures

Genetic architecture of subcortical brain structures

Planar cell polarity pathway and development of the human visual cortex

Planar cell polarity pathway and development of the human visual cortex

Literature review of imaging research of neurodegeneration

Literature review of imaging research of neurodegeneration