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Adams Lab for

Precision
Epidemiology

The Adams lab focuses on improving our fundamental understanding and clinical care of neurodegenerative disorders and cancer. The core basis of our group is deep characterization of large populations.

Latest news

Cortical regions of interest GWAS published in Nature Communications

A genome-wide association study investigating the genetic underpinnings of cortical brain structures was recently published in Nature Communications.

End of summer kayak trip

Every now and then it’s important to clear the heads and relax a bit. So the Adams Lab team went for a nice paddle at Outdoor Valley just outside of Rotterdam.

BDNF gene variants and hippocampal subfields

Natalia Vilor-Tejedor recently led a study in which they investigated whether there is an impact of BDNF Val66Met polymorphism on the volumes of the hippocampal subfields in cognitively unimpaired individuals, as well as whether there exists an interactive effect with the APOE-ε4 the genotype.

Head size and cancer share genetic pathways

Maria Knol and Hieab Adams recently co-led a joint effort between the CHARGE and ENIGMA consortiums investigating the biological pathways underlying the size of the human head.

Letter to parliament on science funding

Pleading for more funding dedicated to Open Research.

Subcortical GWAS published in Nature Genetics

The GWAS of subcortical brain structures, led by Claudia Satizabal and Hieab Adams, was published in Nature Genetics!

Call for collaborators in the UNITED consortium

Call published in The Lancet Neurology marks official launch of the UNITED consortium to the wider academic public.

Visiting scientist Dr. Pawlak

We’re delighted to receive neurologist Dr. Mikolaj Pawlak to our group thanks to a European grant.

Research lines

Imaging Core

The Imaging Core focuses on structural imaging of the human body in a fine-grained approach. This includes high-dimensional imaging markers, consisting of millions of variables describing organ structure. We have a strong focus on brain imaging, but also work with whole-body MRI and CT scanning.

Omics Core

The Omics Core uses high-throughput assessments of biological molecules to understand the physiology and origins of diseases. This spans genomics, epigenomics, and transcriptomics, but we are also exploring new possibilities with the metabolome, proteome and microbiome.

Translational Core

The Translational Core is dedicated to bring epidemiological research to the bench and/or bedside, and vice versa. This includes translating observations into functional studies and clinical implementations, but also taking insights from patients or experiments and testing these in large populations.